Affiliates' Research in Medical Journals, Fall 2020

10/30/2020

Many NBER-affiliated researchers publish some of their findings in medical and other journals that preclude pre-publication distribution. This makes it impossible to include these papers in the NBER Working Paper Series. This is a partial listing of recent papers in this category by NBER affiliates.
 


Behavioral Heuristics in Coronary-Artery Bypass Graft Surgery
Olenski AR, Zimerman A, Coussens S, Jena AB. New England Journal of Medicine 382(8), February 2020, pp. 778–779.
 
Behavioral heuristics (mental shortcuts that simplify decision making) are common in medicine and can lead to cognitive biases that affect clinical decisions. Left-digit bias is the tendency to categorize continuous variables on the basis of the left-most numeric digit. This study examined the effect of this bias on medical treatment decisions. Using data on Medicare beneficiaries from 2006 through 2012, the researchers found that patients who were hospitalized with acute myocardial infarction in the two weeks after their 80th birthday were significantly less likely to undergo coronary-artery bypass grafting (CABG) than similar patients admitted in the two weeks before their 80th birthday, despite an absence of recommendations in clinical guidelines to reduce CABG use at this age. This effect was not found for those admitted in the two weeks before or after their 77th through 79th or 81st through 83rd birthdays. These findings suggest that patients who are hospitalized with acute myocardial infarction and who are 80 years and two weeks of age may be perceived by physicians as being at greater risk for complications—and thus may receive more conservative treatment—than patients who are 79 years and 50 weeks of age, if cognitive biases lead physicians to discretely categorize patients as being “in their 80s” rather than “in their 70s.” The consequences of such bias are significant, since the researchers also found higher mortality among patients admitted shortly after their 80th birthday, adjusted for covariates.

 


Social Distancing Responses to COVID-19 Emergency Declarations Strongly Differentiated by Income
Weill JA, Stigler M, Deschenes O, Springborn MR. PNAS 117(33), August 2020, pp. 19658–19660.
 
In the absence of a vaccine, social distancing measures are one of the primary tools to reduce the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, which causes coronavirus disease 2019 (COVID-19). This study demonstrated that social distancing following US state-level emergency declarations substantially varied by income. Using mobility measures derived from mobile device location pings and an event study design focusing on behavior subsequent to state emergency orders, the researchers documented a reversal in the ordering of social distancing by income: high-income areas went from most mobile before the pandemic to least mobile, while, for multiple measures, the poorest areas went from least mobile to most. The data and analysis in this brief report did not allow for disentangling the causal roles of different factors affecting social distancing behavior, which may involve unequal access to information, differences in mapping of information into subjective probabilities of outcomes and risk preferences, and constraints affecting capacity or ability to respond. Constraints might include limits on capacity to work from home and on the ability to take paid or unpaid time off from work. The finding that lower income communities exhibit less social distancing, combined with prior findings of higher levels of preexisting health conditions and lower access to healthcare in these communities, suggests a double burden of the COVID-19 pandemic with stark distributional implications.
 

 

Changes in the way health insurers pay healthcare providers may not only directly affect the insurers’ patients but may change the providers’ behavior in ways that also affect patients covered by other insurers. Using Medicare data from 2013–2017, the researchers tested for such spillovers in the context of a nationwide Medicare bundled payment reform for hip and knee replacements that was implemented in some areas of the country but not in others, via random assignment. The researchers estimated that the payment reform—which targeted traditional Medicare patients—had effects of similar magnitude and direction on the healthcare experience of nontargeted, privately insured Medicare Advantage patients. They found that the payment reform reduced the share of both traditional Medicare and Medicare Advantage patients being discharged to institutional post-acute care. The fact that providers change their treatment of nontargeted patients suggests that effects on these nontargeted patients need to be accounted for in analyses of a policy’s impact or optimal design. Study results may also be biased if the ‘control group’ of patients not targeted by the policy are also indirectly affected.


Contributions of Public Health, Pharmaceuticals, and Other Medical Care to US Life Expectancy Changes, 1990-2015
Buxbaum JD, Chernew ME, Fendrick AM, Cutler DM. Health Affairs 39(9), September 2020, pp. 1546–1556.

Life expectancy in the US increased 3.3 years between 1990 and 2015. To better understand the drivers of this increase, this study used vital statistics data and cause-deletion analysis to identify the conditions most responsible for changing life expectancy and quantified how public health, pharmaceuticals, other (nonpharmaceutical) medical care, and other/unknown factors contributed to the improvement. The researchers found that 12 conditions most responsible for changing life expectancy explained 2.9 years of net improvement (85 percent of the total). Ischemic heart disease was the largest positive contributor to life expectancy, and accidental poisoning or drug overdose was the largest negative contributor. Medications with the largest impacts included antiretroviral therapy for HIV, statins for ischemic heart disease, and surfactant and antenatal steroids for low-birthweight babies. Public health improvements were driven by smoking reduction, and increased adoption of known risk reduction practices such as seatbelt usage, putting infants to sleep on their backs, and traffic safety. Forty-four percent of improved life expectancy was attributable to public health, 35 percent was attributable to pharmaceuticals, 13 percent was attributable to other medical care, and -7 percent was attributable to other/unknown factors. These findings emphasize the crucial role of public health advances, as well as pharmaceutical innovation, in explaining improvements in life expectancy.

 


The Impact of the COVID-19 Pandemic on Hospital Admissions in the United States
Birkmeyer JD, Barnato A, Birkmeyer N, Bessler R, Skinner J. Health Affairs 39(11), September 2020.
 

Hospital admissions in the US fell dramatically with the onset of the COVID-19 pandemic. Using data on approximately 1 million medical admissions from a large nationally representative hospitalist group, the researchers found that declines in non-COVID-19 admissions from February to April 2020 were generally similar across patient demographic subgroups and exceeded 20 percent for all primary admission diagnoses. Patients likely avoided seeking hospital care, perhaps in response to fear of contagion arising from media reports, or as a result of state stay-at-home orders. Relatively advantaged populations may have had greater access to ambulatory care resources for safely deferring hospital-based care, including telemedicine services, which increased dramatically during the pandemic. By late June/early July 2020, overall non-COVID-19 admissions had rebounded to 16 percent below pre-pandemic baseline volume (8 percent including COVID-19 admissions). Admissions remained depressed in hospitals with the largest COVID-19 exposure (23 percent below baseline), while admissions had rebounded nearly completely for hospitals with the least COVID-19 exposure (-7 percent). Non-COVID-19 patients who were age 70 or over continued to have a larger decline relative to baseline (-19 percent) than younger patients. Non-COVID-19 admissions also remained 20 percent below baseline for self-pay patients during the rebound. This finding could reflect changes in health care decisions and/or access among people who became uninsured due to job loss during the pandemic. Non-COVID-19 admissions remained substantially lower for patients residing in majority-Hispanic neighborhoods (32 percent below baseline). This pattern may reflect COVID-19 resurgences in Hispanic areas of the country in late June, but a larger concern is that it may reflect access challenges for Hispanic populations. Across the whole population, admissions in late June/early July 2020 had returned to baseline levels for pancreatitis, alcohol-related conditions, and diabetes, but remained well below baseline for patients with pneumonia (-44 percent), COPD/asthma (-40 percent), sepsis (-25 percent), urinary tract infection (-24 percent), as well as for acute ST-elevation myocardial infarction (-22 percent), and stroke (-17 percent), two acute conditions generally requiring immediate hospitalization to avoid adverse outcomes. The researchers discuss potential explanations for the reduced admissions, which include lower incidence of disease as well as elevated out-of-hospital deaths.
 



Did the ACA Lower Americans’ Financial Barriers to Health Care?
Glied SA, Collins SR, Lin S. Health Affairs 39(3), March 2020, pp. 379–386.
 

Obesity and Incident Prescription Opioid Use in the US, 2000−2015
Stokes A, Lundberg DJ, Hempstead K, Berry KM, Baker JF, Preston SH. American Journal of Preventative Medicine 58(6), April 2020, pp. 766−775.
 

 

Effects of a Scalable Home‐Visiting Intervention on Child Development in Slums of Urban India: Evidence from a Randomised Controlled Trial
Andrew A, Attanasio O, Augsburg B, Day M, Grantham‐McGregor S, Meghir C, Mehrin F, Pahwa S, Rubio‐Codina M. The Journal of Child Psychology and Psychiatry 61(6), June 2020, pp. 644–652.
 

 

Two Indias: The Structure of Primary Health Care Markets in Rural Indian Villages with Implications for Policy
Das J, Daniels B, Ashok M, Shim EY, Muralidharan K. Social Science and Medicine, June 2020, 112799.
 

 

 

Public Insurance Expansions and Mental Health Care Availability
Blunt EO, Maclean JC, Popovici I, Marcus SC. Health Services Research 55, July 2020, pp. 615–625.
 

Do Physician Incentives Increase Patient Medication Adherence?
Kong E, Beshears J, Laibson D, Madrian B, Volpp K, Loewenstein G, Kolstad J, Choi JJ. Health Services Research 55(4), July 2020, pp. 503–511.
 

The Social, Political, and Economic Effects of the Affordable Care Act: Introduction to the Issue
Campbell AL, Shore-Sheppard L. The Russell Sage Foundation Journal of the Social Sciences 6(2), July 2020, pp. 1–40.
 

What’s Left of the Affordable Care Act? A Progress Report
Levy H, Ying A, Bagley N. The Russell Sage Foundation Journal of the Social Sciences 6(2), July 2020, pp. 42–66.
 

The Full Impact of the Affordable Care Act on Political Participation
Courtemanche C, Marton J, Yelowitz A. The Russell Sage Foundation Journal of the Social Sciences 6(2), July 2020, pp. 179–204.
 

Medicaid Expansion’s Spillover to the Criminal Justice System: Evidence from Six Urban Counties
Fry CE, McGuire TG, Frank RG. The Russell Sage Foundation Journal of the Social Sciences 6(2), July 2020, pp. 244–263.
 

 

Birth Month and Influenza Vaccination in Children
Worsham C, Woo J, Jena AB. New England Journal of Medicine 383(2), July 2020, pp. 184–185.
 

 

Economic Vulnerability of Households with Essential Workers
McCormack G, Avery C, Kahn-Lang Spitzer A, Chandra A. JAMA 324(4), July 2020, pp. 388–390.
 

 

Trends in New Diagnoses of Atrial Fibrillation after Release of an ECG-Capable Smartwatch
Zimerman A, Sheridan B, Cooke S, Jena AB. Circulation 142(8), August 2020, pp. 814–816.
 

Estimates of the Association of Dementia with US Mortality Levels Using Linked Survey and Mortality Records
Stokes AC, Weiss J, Lundberg DJ, Xie W, Kim JK, Preston SH, Crimmins EM. JAMA Neurology, August 2020.
 

Attributing Medical Spending to Conditions: A Comparison of Methods
Ghosh K, Bondarenko I, Messer KL, Stewart ST, Raghunathan T, Rosen AB, Cutler DM. PLOS ONE 15(8), August 2020, e0237082.
 

 

Emergency Visits for Thunderstorm-Related Respiratory Illnesses among Older Adults
Zou E, Worsham C, Miller NH, Molitor D, Reif J, Jena AB. JAMA Internal Medicine 180(9), August 2020, pp. 1248–1250.
 

Effects of the Recent Medicaid Expansions on Dental Preventive Services and Treatments
Lyu W, Shane D, Wehby GL. Medical Care 58(8), August 2020, pp. 749–755.
 

 
Association of COVID-19- Related Hospital Use and Overall COVID-19 Mortality in the USA
Karaca-Mandic P, Sen S, Georgiou A, Zhu Y, Basu A. Journal of General Internal Medicine, August 2020.
 

Assessment of COVID-19 Hospitalizations by Race/Ethnicity in 12 States
Karaca-Mandic P, Georgiou A, Sen S. JAMA Internal Medicine, August 2020.
 

Ecological Factors Associated with Suicide Mortality among Non-Hispanic Whites
Graetz N, Preston SH, Peele M, Elo IT. BMC Public Health 20, September 2020, 1339.
 

Patient and Provider-Level Factors Associated with Changes in Utilization of Treatments in Response to Evidence on Ineffectiveness or Harm
Smith LB, Desai N, Dowd B, Everhart A, Herrin J, Higuera L, Jeffery M, Jena AB, Ross J, Shah N, Karaca-Mandic P. International Journal of Health Economics and Management 20(3), September 2020, pp. 299–317.
 

The Importance of Data Source in Prescription Drug Monitoring Program Research
Horwitz JR, Davis C, McClelland L, Fordon R, Meara E. Health Services Research, September 2020.
 

 

 

Regulating Opioid Supply through Insurance Coverage
Auld MC, Horwitz JR, Lukenchuk B, McClelland L. Health Affairs 39(9), September 2020.
 

Financial Incentives to Promote Retention in Care and Viral Suppression in Adults with HIV Initiating Antiretroviral Therapy in Tanzania: A Three-Arm Randomised Controlled Trial
Fahey CA, Njau PF, Katabaro E, Mfaume RS, Ulenga N, Mwenda N, Bradshaw PT, Dow WH, Padian NS, Jewell NP, McCoy SI. The Lancet HIV, September 2020.
 

Preliminary Assessment of a Novel Continuum-of-Care Model for Young People with Autism Spectrum Disorders
Cummings MR, Dubovsky SL, Ehrlich I, Kandefer S, Van Cleve J, Yin Y, Cranwell V, Gordon J, Youngs M. Psychiatric Services, September 2020.
 

ADHD, Financial Distress, and Suicide in Adulthood: A Population Study
Beauchaine TP, Ben-David I, Bos M. Science Advances 6(40), September 2020, eaba1551.
 

 

Allocation of COVID-19 Relief Funding to Disproportionately Black Counties
Kakani P, Chandra A, Mullainathan S, Obermeyer Z. JAMA 324(10), September 2020, pp. 1000–1003.
 

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing
Pian J, Chandra A, Stern AD. NEJM Catalyst Innovations in Care Delivery 1(5), September-October 2020.
 

Are Changes in Medical Group Practice Characteristics over Time Associated with Medicare Spending and Quality of Care?
Baker LC, Pesko M, Ramsay P, Casalino LP, Shortell SM. Medical Care Research and Review 77(5), October 2020, pp. 402–415.
 

 

Economy-Sensitive Conditions: Are Some Pediatric Hospitalizations Triggered by Economic Recessions?
Colvin JD, Richardson T, Ginther DK, Hall M, Chung PJ. Health Affairs 39(10), October 2020.
 

Decoding the Mystery of American Pain Reveals a Warning for the Future
Case A, Deaton A, Stone AA. PNAS 117(40), October 2020, pp. 24785–24789.
 

Trends in Extreme Distress in the United States, 1993–2019
Blanchflower DG, Oswald AJ. American Journal of Public Health 110(10), October 2020, pp. 1538–1544.
 

The Effects of Market Competition on Cardiologists’ Adoption of Transcatheter Aortic Valve Replacement
Groeneveld P, Yang L, Segal A, Karaca-Mandic P, Kanter G. Medical Care 58(11), November 2020, pp. 996–1003.
 

Peer Effects in Smoking Cessation: An Instrumental Variables Analysis of a Worksite Intervention in Thailand
Lowenstein C, Dow WH, White JS. SSM - Population Health 12, December 2020, 100659.
 

Education and Adult Mortality in Middle-Income Countries: Surprising Gradients in Six Nationally-Representative Longitudinal Surveys
Sudharsanan N, Zhang Y, Payne CF, Dow W, Crimmins E. SSM - Population Health 12, December 2020, 100649.
 

Increases in BMI and Chronic Pain for US Adults in Midlife, 1992 to 2016
Stokes AC, Xie W, Lundberg DJ, Hempstead K, Zajacova A, Zimmer Z, Glei DA, Meara E, Preston SH. SSM - Population Health 12, December 2020, 100644.