We would like to thank Catherine Barrera, Benno Buehler, Christopher Cairns, Yi Chen, Iain Cockburn, Florian Ederer, Chris Forman, Soheil Ghili, George Jakubson, Shulamit Khan, Francine Lafontaine, Jorge Lemus, Scott Masten, Marcel Preuss, Mark Satterthwaite, Christian Schmid, Jagadeesh Sivadasan, Scott Stern, Chad Syversen, Rainer Widmann, Heidi Williams, unnamed seminar participants, in particular at Cornell University and the University of Michigan, as well as those of the first virtual 2020 Annual Conference of the Society for Institutional and Organizational Economics (SIOE 2020), the 2021 ZEW Annual Conference of the Mannheim Centre for Competition and Innovation (MaCCI 2021), the 2021 Annual Conference of the Royal Economic Society (RES 2021), the 2024 International Industrial Organization Conference (IIOC 2024), and the 2025 Productivity Lunch Seminar at NBER for helpful comments, Kiran Butte, Yuhan Chen, Yujie Feng, Qiwei He, Rebecca Herzberg, and Douglas Weinstein for valuable research assistance, and Wyatt Gotbetter for valuable industry insights. We are particularly grateful to three anonymous referees and the editor, Daniel Yi Xu. All remaining errors are our own. Earlier drafts of this paper were circulated under the titles “The Organization of Innovation: Theory and Evidence from the Pharmaceutical Industry,” and “The Organization of Innovation: Property Rights and the Outsourcing Decision.” The authors have contributed equally and are listed alphabetically. The views expressed herein are those of the authors and do not necessarily reflect the views of the National Bureau of Economic Research.