National Bureau of Economic Research

The hepatitis C virus (HCV) is a major public health concern due to its high infection and mortality rates. Recent pharmaceutical innovations known as direct-acting antivirals (DAAs) have the potential to cure HCV and can also generate positive health externalities through reduced transmission. However, the high cost of these drugs—with a sticker price of approximately $84,000 for the course of treatment when initially introduced in 2013—creates substantial obstacles to their use under traditional reimbursement schemes and in cash-strapped Medicaid programs.

In Subscriptions to Prescriptions: Lessons from Louisiana’s Effort to Eliminate Hepatitis C (NBER Working Paper 33617), James M. Flynn, Bethany I. Lemont, and Barton Willage evaluate the effects of the Louisiana Hepatitis C Elimination Plan...

The Development of the American Economy (DAE) program was one of the first research programs launched by Martin Feldstein in 1978 when he formalized the modern structure of the NBER.

The mission of the program is to research historical aspects of the American economy. Its members are economic historians whose specific interests span many subfields within economics, including macroeconomics, labor economics, finance, political economy, trade, and industrial organization. Broadly, economic history research comes in two flavors. First, economic historians study the evolution of economic trends that illuminate issues relevant to the modern economy, such as the entry of women in the labor force and the moderation of economic crises over time. Second, economic historians use the natural experiments offered by history to test economic…

The surge in remote work in recent years has transformed labor markets, with potentially important implications for the interaction between workplace flexibility and entrepreneurship. In Hustling from Home? Work from Home Flexibility and Entrepreneurial Entry (NBER Working Paper 33237), John M. Barrios, Yael Hochberg, and Hanyi (Livia) Yi explore whether the increased flexibility provided by work-from-home (WFH) arrangements has affected entrepreneurial decisions. They focus on the COVID-19 pandemic as a natural experiment and analyze how the sudden shift to remote work affected new business creation. Guided…

Naloxone, which reverses the effects of an opioid overdose, is a critical tool for responding to the opioid crisis. However, prior to the 2010s, two barriers hindered its widespread distribution and use in the United States. One was legal access: Naloxone required a prescription from a healthcare provider. Another was that naloxone was administered by injection and therefore required training for proper use. 

In 2010, Illinois became the first state to adopt a dispensing naloxone access law (NAL) that permitted individuals to obtain naloxone directly from pharmacists, eliminating the need for an individual prescription. By 2015, another 35 states had implemented dispensing NALs. These policy initiatives were complemented by the introduction of Narcan, the first FDA-approved naloxone nasal spray, in 2016. This new…