TY - JOUR AU - Ashlagi,Itai AU - Gamarnik,David AU - Rees,Michael A. AU - Roth,Alvin E. TI - The Need for (long) Chains in Kidney Exchange JF - National Bureau of Economic Research Working Paper Series VL - No. 18202 PY - 2012 Y2 - July 2012 UR - http://www.nber.org/papers/w18202 L1 - http://www.nber.org/papers/w18202.pdf N1 - Author contact info: Itai Ashlagi Massachusetts Institute of Technology Sloan School of Management, E62-577 Cambridge, MA 02142 E-Mail: iashlagi@mit.edu David Gamarnik Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge, MA 02139 E-Mail: gamarnik@mit.edu Michael A. Rees University of Toledo Department of Urology 3000 Arlington Avenue Mail Stop 1091 Toledo, OH 43614 E-Mail: michael.rees2@utoledo.edu Alvin E. Roth Department of Economics Stanford University 579 Serra Mall Stanford, CA 94305 Tel: 650/725-9147 E-Mail: alroth@stanford.edu AB - It has been previously shown that for sufficiently large pools of patient-donor pairs, (almost) efficient kidney exchange can be achieved by using at most 3-way cycles, i.e. by using cycles among no more than 3 patient-donor pairs. However, as kidney exchange has grown in practice, cycles among n>3 pairs have proved useful, and long chains initiated by non-directed, altruistic donors have proven to be very effective. We explore why this is the case, both empirically and theoretically. We provide an analytical model of exchange when there are many highly sensitized patients, and show that large cycles of exchange or long chains can significantly increase efficiency when the opportunities for exchange are sparse. As very large cycles of exchange cannot be used in practice, long non-simultaneous chains initiated by non-directed donors significantly increase efficiency in patient pools of the size and composition that presently exist. Most importantly, long chains benefit highly sensitized patients without harming low-sensitized patients. ER -