TY  - JOUR
AU  - Ludwig,Jens
AU  - Marcotte,Dave E.
AU  - Norberg,Karen
TI  - Anti-depressants and Suicide
JF  - National Bureau of Economic Research Working Paper Series
VL  - No. 12906
PY  - 2007
Y2  - February 2007
UR  - http://www.nber.org/papers/w12906
L1  - http://www.nber.org/papers/w12906.pdf
N1  - Author contact info:
Jens Ludwig
University of Chicago
1155 East 60th Street
Chicago, IL 60637
Tel: 773/834-0811
Fax: 773/834-1582
E-Mail: jludwig@uchicago.edu

Dave Marcotte
Department of Public Policy
UMBC
1000 Hilltop Circle
Baltimore, MD 21250
Tel: 410/455-1455
Fax: 410/455-1172
E-Mail: marcotte@umbc.edu

Karen Norberg
18 S. Kingshighway Blvd
Apt 16A
St. Louis, MO 63108
Tel: 314/454-9623
E-Mail: norberg@nber.org
AB  - Does drug treatment for depression with selective serotonin reuptake inhibitors (SSRIs) increase or decrease the risk of completed suicide?  The question is important in part because of recent government warnings that question the safety of SSRIs, one of the most widely prescribed medications in the world.  While there are plausible clinical and behavioral arguments that SSRIs could have either positive or negative effects on suicide, randomized clinical trials have not been very informative because of small samples and other problems.  In this paper we use data from 26 countries for up to 25 years to estimate the effect of SSRI sales on suicide mortality using just the variation in SSRI sales that can be explained by cross-country variation in the growth of drug sales more generally.  We find that an increase in SSRI sales of 1 pill per capita (about a 12 percent increase over 2000 sales levels) is associated with a decline in suicide mortality of around 5 percent.  These estimates imply a cost per statistical life far below most other government interventions to improve health outcomes.
ER  -